The isomorphism type of the knot quandle introduced by Joyce is a complete invariant of tame knots. Whether two quandles are isomorphic is in practice difficult to determine; we show that this question is provably hard: isomorphism of quandles is Borel complete. The class of tame knots, however, is trivial from the perspective of Borel equivalence, suggesting that a less complex complete invariant of tame knots likely exists.